DrugMap cysteine engagement data for:
Probe: KB05 KB03 | Download Table Download Statistics |
name | peptide | bone_CAL72 | bone_U2OS | bone_SAOS2 | bone_SJSA1 | bone_SKNMC | bone_A673 | bone_SKES1 | bone_TC71 | bone_CAL78 |
---|---|---|---|---|---|---|---|---|---|---|
CYS 152 | IISNASCTTNCLAPLAK | 46 | 10 | 43 | 39 | |||||
LTGMAFRVPTANVSVVDLTCR | 15 | 7 | 10 | 6 | 1 | 5 | 12 | 10 | 4 | |
GAPDH | DNA copy number | 1.27989371101424 | 1.3101800861809 | 0.99620600188325 | 1.09053315061192 | 1.01519165168247 | 1.11575216684588 | 1.23042597680852 | 0.687331195647811 | 1.28485975164314 |
GAPDH | DNA mutation status | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
GAPDH | RNA expression | 12.9726208620587 | 12.7838167593202 | 11.9957318249056 | 12.5674570333189 | 11.9035806253486 | 12.0889538278179 | 12.4388438219247 | 11.6171000868759 | 12.8587386774159 |
GAPDH | CRISPR gene dependency | 0.98 | 0.98 | 1.00 | 1.00 | 0.96 | 1.00 | 1.00 | 1.00 |
Structural information (To highlight a cysteine, click a "CYS" button)
Cysteine | Gene | Uniprot Accession | pdb | Depth (Å) | Absolute SASA (Å^2) | Half-Sphere Exposure (up) | Half-Sphere Exposure (down) | Coordination Number | Relative SASA | Estimated h_nho1 energy (DSSP) | Estimated h_ohn1 energy (DSSP) | Estimated h_nho2 energy (DSSP) | Estimated h_ohn2 energy (DSSP) | TCO (DSSP) | Kappa (DSSP) | Alpha (DSSP) | Phi (DSSP) | Psi (DSSP) | Structural Motif (DSSP) | Pocket Volume (Å^3) | Presence at Interface | Local Basic Content (Fraction of Local Neighbors) | Local Acidic Content (Fraction of Local Neighbors) | Local Polar Content (Fraction of Local Neighbors) | Local Cysteine Content (Fraction of Local Neighbors) | Local Structural Content (Fraction of Local Neighbors) | Local Aliphatic Content (Fraction of Local Neighbors) | Local Aromatic Content (Fraction of Local Neighbors) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GAPDH | P04406 | 6ynd | 7.2 | 0.0 | 25.0 | 24.0 | 49.0 | 0.0 | -2.5 | -2.2 | -0.6 | -0.5 | -0.9 | 37.5 | -135.7 | -134.8 | 154.6 | E | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.7 | 0.0 |
Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell
and Lawrence Lab