DrugMap cysteine engagement data for:
Probe: KB05 KB03 | Download Table Download Statistics |
name | peptide | cervix_SISO | cervix_HT3 | cervix_CASKI | cervix_C4II | cervix_DOTC24510 | cervix_SW756 |
---|---|---|---|---|---|---|---|
CYS 152 | IISNASCTTNCLAPLAK | 44 | 50 | 35 | 43 | 29 | 43 |
LTGMAFRVPTANVSVVDLTCR | 1 | 16 | 9 | 8 | 9 | 6 | |
GAPDH | DNA copy number | 0.951405520167152 | 1.14703447554072 | 0.942086201054676 | 0.596322460055657 | 0.983920616318187 | 1.41921512439156 |
GAPDH | DNA mutation status | 0 | 0 | 0 | 0 | 0 | 0 |
GAPDH | RNA expression | 12.3198978771545 | 11.0011266654543 | 11.3287310185797 | 11.3162249543607 | 11.2451961477728 | 13.8675683309001 |
GAPDH | CRISPR gene dependency | 1.00 | 0.93 | 1.00 | 0.70 | 0.86 | 0.99 |
Structural information (To highlight a cysteine, click a "CYS" button)
Cysteine | Gene | Uniprot Accession | pdb | Depth (Å) | Absolute SASA (Å^2) | Half-Sphere Exposure (up) | Half-Sphere Exposure (down) | Coordination Number | Relative SASA | Estimated h_nho1 energy (DSSP) | Estimated h_ohn1 energy (DSSP) | Estimated h_nho2 energy (DSSP) | Estimated h_ohn2 energy (DSSP) | TCO (DSSP) | Kappa (DSSP) | Alpha (DSSP) | Phi (DSSP) | Psi (DSSP) | Structural Motif (DSSP) | Pocket Volume (Å^3) | Presence at Interface | Local Basic Content (Fraction of Local Neighbors) | Local Acidic Content (Fraction of Local Neighbors) | Local Polar Content (Fraction of Local Neighbors) | Local Cysteine Content (Fraction of Local Neighbors) | Local Structural Content (Fraction of Local Neighbors) | Local Aliphatic Content (Fraction of Local Neighbors) | Local Aromatic Content (Fraction of Local Neighbors) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GAPDH | P04406 | 6ynd | 7.2 | 0.0 | 25.0 | 24.0 | 49.0 | 0.0 | -2.5 | -2.2 | -0.6 | -0.5 | -0.9 | 37.5 | -135.7 | -134.8 | 154.6 | E | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.7 | 0.0 |
Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell
and Lawrence Lab