DrugMap: GAPDH (KB02)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   KB05
KB05
   KB03
KB03
   
KB02
KB02
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namepeptideinformation
soft_tissue_RKN
soft_tissue_A204
soft_tissue_KYM1
soft_tissue_HT1080
soft_tissue_RD
soft_tissue_RH30
soft_tissue_RH41
CYS 152 IISNASCTTNCLAPLAK4442274239
LTGMAFRVPTANVSVVDLTCR-5322372-2
GAPDHDNA copy numberinformation1.267960914980151.028995649315411.041713125632870.9959078202118051.021586619170620.9944133588186530.694741249968906
GAPDHDNA mutation statusinformation0000000
GAPDHRNA expressioninformation13.285373318431713.101499726252211.707488554658412.886992081786612.142107057302512.804272217647310.7091699924758
GAPDHCRISPR gene dependencyinformation0.960.861.001.000.95

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab