DrugMap cysteine engagement data for:
Probe: KB05 KB03 | Download Table Download Statistics |
name | peptide | upper_aerodigestive_DETROIT562 | upper_aerodigestive_BICR22 | upper_aerodigestive_CAL27 | upper_aerodigestive_HSC3 | upper_aerodigestive_FADU | upper_aerodigestive_CAL33 | upper_aerodigestive_SCC25 | upper_aerodigestive_HSC4 |
---|---|---|---|---|---|---|---|---|---|
CYS 152 | IISNASCTTNCLAPLAK | 4 | 3 | 34 | 7 | ||||
LTGMAFRVPTANVSVVDLTCR | 7 | 11 | 15 | 5 | |||||
GAPDH | DNA copy number | 1.07145064628669 | 0.990595354762458 | 1.05454723702631 | 1.12922628201505 | 1.24786173532313 | 0.997045531409922 | 1.12601297965653 | 1.09419604097632 |
GAPDH | DNA mutation status | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
GAPDH | RNA expression | 11.5913820907214 | 9.66473170654862 | 11.9245156222299 | 12.611785609073 | 12.6485822833637 | 11.0209799389042 | 11.3261485612056 | 11.1502550213022 |
GAPDH | CRISPR gene dependency | 0.96 | 0.98 | 1.00 | 0.89 | 0.98 | 0.99 | 1.00 | 1.00 |
Structural information (To highlight a cysteine, click a "CYS" button)
Cysteine | Gene | Uniprot Accession | pdb | Depth (Å) | Absolute SASA (Å^2) | Half-Sphere Exposure (up) | Half-Sphere Exposure (down) | Coordination Number | Relative SASA | Estimated h_nho1 energy (DSSP) | Estimated h_ohn1 energy (DSSP) | Estimated h_nho2 energy (DSSP) | Estimated h_ohn2 energy (DSSP) | TCO (DSSP) | Kappa (DSSP) | Alpha (DSSP) | Phi (DSSP) | Psi (DSSP) | Structural Motif (DSSP) | Pocket Volume (Å^3) | Presence at Interface | Local Basic Content (Fraction of Local Neighbors) | Local Acidic Content (Fraction of Local Neighbors) | Local Polar Content (Fraction of Local Neighbors) | Local Cysteine Content (Fraction of Local Neighbors) | Local Structural Content (Fraction of Local Neighbors) | Local Aliphatic Content (Fraction of Local Neighbors) | Local Aromatic Content (Fraction of Local Neighbors) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GAPDH | P04406 | 6ynd | 7.2 | 0.0 | 25.0 | 24.0 | 49.0 | 0.0 | -2.5 | -2.2 | -0.6 | -0.5 | -0.9 | 37.5 | -135.7 | -134.8 | 154.6 | E | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.7 | 0.0 |
Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell
and Lawrence Lab