DrugMap cysteine engagement data for:
Probe: KB05 KB03 | Download Table Download Statistics |
name | peptide | uterus_HEC1 | uterus_AN3CA | uterus_MFE296 | uterus_RL952 | uterus_MFE280 | uterus_ISHIKAWAHERAKLIO02ER | uterus_SNGM | uterus_SKN | uterus_MFE319 |
---|---|---|---|---|---|---|---|---|---|---|
CYS 152 | IISNASCTTNCLAPLAK | 27 | 29 | 31 | 41 | 53 | 54 | 32 | ||
LTGMAFRVPTANVSVVDLTCR | -3 | 5 | -8 | -2 | -15 | -21 | 3 | 2 | -2 | |
GAPDH | DNA copy number | 0.875222265424104 | 0.988382654483111 | 1.03391448788747 | 1.02983423924618 | 0.919344287561173 | 1.30211685737862 | 1.02963475115625 | 1.09038252051117 | 1.03755287079235 |
GAPDH | DNA mutation status | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
GAPDH | RNA expression | 12.0097586498596 | 12.017817542602 | 12.1723024863272 | 11.5276236139606 | 10.7991196937996 | 12.3960963235333 | 11.4828583644778 | 12.6524640870801 | 11.9489876906477 |
GAPDH | CRISPR gene dependency | 0.97 | 1.00 | 1.00 | 0.79 | 0.88 | 1.00 | 0.94 | 0.62 |
Structural information (To highlight a cysteine, click a "CYS" button)
Cysteine | Gene | Uniprot Accession | pdb | Depth (Å) | Absolute SASA (Å^2) | Half-Sphere Exposure (up) | Half-Sphere Exposure (down) | Coordination Number | Relative SASA | Estimated h_nho1 energy (DSSP) | Estimated h_ohn1 energy (DSSP) | Estimated h_nho2 energy (DSSP) | Estimated h_ohn2 energy (DSSP) | TCO (DSSP) | Kappa (DSSP) | Alpha (DSSP) | Phi (DSSP) | Psi (DSSP) | Structural Motif (DSSP) | Pocket Volume (Å^3) | Presence at Interface | Local Basic Content (Fraction of Local Neighbors) | Local Acidic Content (Fraction of Local Neighbors) | Local Polar Content (Fraction of Local Neighbors) | Local Cysteine Content (Fraction of Local Neighbors) | Local Structural Content (Fraction of Local Neighbors) | Local Aliphatic Content (Fraction of Local Neighbors) | Local Aromatic Content (Fraction of Local Neighbors) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GAPDH | P04406 | 6ynd | 7.2 | 0.0 | 25.0 | 24.0 | 49.0 | 0.0 | -2.5 | -2.2 | -0.6 | -0.5 | -0.9 | 37.5 | -135.7 | -134.8 | 154.6 | E | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.7 | 0.0 |
Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell
and Lawrence Lab