DrugMap: GAPDH (KB03)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   KB05
KB05
   
KB03
KB03
   KB02
KB02
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namepeptideinformation
bile_duct_ICC21
bile_duct_ICC137
bile_duct_ICC10
bile_duct_ICC106
bile_duct_SNU245
bile_duct_ICC11
bile_duct_ICC108
bile_duct_ICC24
bile_duct_TGBC1TKB
bile_duct_ICC20
bile_duct_ICC8
bile_duct_KMCH1
bile_duct_ICC26
bile_duct_TFK1
bile_duct_ICC3
bile_duct_ICC18
bile_duct_SNU1079
bile_duct_RBE
bile_duct_YSCCC
bile_duct_ETK1
bile_duct_ECC2
bile_duct_EGI1
bile_duct_SNU869
bile_duct_SNU1196
bile_duct_OCUG1
bile_duct_GB2
bile_duct_SNU308
bile_duct_G415
bile_duct_CCSW1
bile_duct_CCLP1
bile_duct_SG231
bile_duct_HUCCT1
bile_duct_TKKK
bile_duct_SNU478
bile_duct_HUH28
bile_duct_ICC12
bile_duct_HKGZCC
bile_duct_TGBC52TKB
bile_duct_ICC9
bile_duct_MG984
bile_duct_OZ
bile_duct_SSP25
bile_duct_ICC19
bile_duct_ICC4
CYS 152 IISNASCTTNCLAPLAK81798787636665887469356039695363334055551856674855425543203656517656537228431422
LTGMAFRVPTANVSVVDLTCR45616763-97962701257252018232820101387526152956234540413028641465782635552731264751
GAPDHDNA copy numberinformation1.110651237868940.8422698904943651.020806403412141.171020837011511.158572041164241.149520704005270.9786518244008411.1796152775640.9971443318586651.030927556942231.030255240898011.168732010279361.036071978764941.128387258239741.021077251127351.027293895836340.9053184787603970.8523076376501051.265363347616541.018261634679311.345350975573451.188342411298091.005924615366521.079323532994611.469294749522560.9888032887281661.024399399140070.8842189909954030.9312304328295181.096528779056830.9309755419026790.9705816920125441.052067430533291.02111986088282
GAPDHDNA mutation statusinformation0000000000000000020000000000000000
GAPDHRNA expressioninformation12.143096177140211.900979985683611.648806949725811.714417256853412.152570056980212.450412255945211.972584964746211.276880458565112.37471348450512.06750158635911.700353015112712.613904544043611.471268764173611.460097481838811.119848958336811.01388093793511.328170007901912.241864012236812.144721964703811.91554330824213.181447351638112.693704739225311.178478122567211.770127014683911.990068498941711.331644762613112.170457147551911.677411340530610.589557522773511.327608778982911.782998208920411.193032468442812.7247056881112.8232876189175
GAPDHCRISPR gene dependencyinformation0.941.001.001.000.960.991.001.001.000.980.980.961.001.000.990.840.841.000.901.001.000.991.000.960.591.000.761.000.981.001.000.98

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab