DrugMap: GAPDH (KB03)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   KB05
KB05
   
KB03
KB03
   KB02
KB02
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namepeptideinformation
blood_CMK
blood_THP1
blood_U937
blood_MONOMAC1
blood_KASUMI1
blood_MOLM13
blood_P31FUJ
blood_OCIAML5
blood_MOLM16
blood_MONOMAC6
blood_JURLMK1
blood_NOMO1
blood_KASUMI2
blood_697
blood_REH
blood_JM1
blood_MV411
blood_KO52
blood_TF1
blood_OCIAML2
blood_NALM6
blood_JVM3
blood_MEC1
blood_HG3
blood_HEL9217
blood_HEL
blood_EOL1
blood_JURKAT
blood_PF382
blood_SUPT1
CYS 152 IISNASCTTNCLAPLAK613939595946485062655561535355583663387177448064715756537148
LTGMAFRVPTANVSVVDLTCR26445418273320827253436343117221144253142303530171718282921
GAPDHDNA copy numberinformation1.048168199230590.5834480931923920.864366182574470.9965626047867641.002951512988180.9774579090857880.9717716836470871.005617895708711.089796044449190.656294684434861.015466021135540.790729264483891.003051219771620.9795864964113550.9928229413559130.9364499312176680.9881133751162540.93895288093740.9230498729672390.9448890693090461.001591877274971.20494747391860.9951945300197221.025830680653421.111741530519791.095285125721290.9752013663050371.01454710981341.036638740024331.00688937142604
GAPDHDNA mutation statusinformation200000000002000000000000000000
GAPDHRNA expressioninformation12.373925475478910.567290647585311.473807201399711.547906691460811.764208130139911.471624414376511.829286689926212.404130371238411.257859234639611.44273619718611.200776025910911.065483454386412.044325808316912.066291045977712.250564900998111.160564773485311.40790504396112.152760168775411.819420709931612.192755142640411.153678689452912.03686044667311.854089179870612.098032082960511.869092552644611.548725597163911.506158790852411.873136468833511.854751529577612.1764225130422
GAPDHCRISPR gene dependencyinformation0.991.000.980.620.990.991.000.841.001.000.970.990.991.001.000.940.991.000.980.990.990.981.001.00

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab