DrugMap: GAPDH (KB03)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   KB05
KB05
   
KB03
KB03
   KB02
KB02
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namepeptideinformation
lymphocyte_HT
lymphocyte_A3KAW
lymphocyte_RL
lymphocyte_KARPAS422
lymphocyte_SUDHL4
lymphocyte_JEKO1
lymphocyte_OCILY3
lymphocyte_SUDHL6
lymphocyte_KARPAS299
lymphocyte_REC1
lymphocyte_L428
lymphocyte_DEL
CYS 152 IISNASCTTNCLAPLAK6569644673643957664256
LTGMAFRVPTANVSVVDLTCR744435464330365145144251
GAPDHDNA copy numberinformation1.011382551660991.028840122983811.278808227625771.016058894169921.282796038542491.20538067810450.9971203796108970.9927438400249231.007002411758270.7218108867242191.194335552835580.991619483214878
GAPDHDNA mutation statusinformation000000000000
GAPDHRNA expressioninformation12.401919466393912.369597346278712.657385446247413.294620748891612.295080132764611.990210353374210.92866641230511.669150812668712.396470993910410.672867276433812.681897226786212.6702800372529
GAPDHCRISPR gene dependencyinformation1.001.000.990.991.000.991.001.00

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab