DrugMap cysteine engagement data for:
Probe: KB05 KB02 | Download Table Download Statistics |
name | peptide | plasma_cell_KMS12BM | plasma_cell_KMS11 | plasma_cell_KMS27 | plasma_cell_RPMI8226 | plasma_cell_OPM2 | plasma_cell_SKMM2 |
---|---|---|---|---|---|---|---|
CYS 152 | IISNASCTTNCLAPLAK | 71 | 42 | 70 | 55 | 64 | 68 |
LTGMAFRVPTANVSVVDLTCR | 55 | 22 | 19 | 31 | 35 | 40 | |
GAPDH | DNA copy number | 1.05547157092619 | 0.974108583286628 | 0.983855851910586 | 1.03988400765034 | 1.20999239155973 | 1.03489711134826 |
GAPDH | DNA mutation status | 0 | 0 | 0 | 0 | 0 | 0 |
GAPDH | RNA expression | 11.1608798618393 | 11.7159619902551 | 11.1245090809596 | 11.5008916611356 | 11.3891473126631 | 10.8833306108866 |
GAPDH | CRISPR gene dependency | 1.00 | 1.00 | 0.98 | 1.00 | 0.92 |
Structural information (To highlight a cysteine, click a "CYS" button)
Cysteine | Gene | Uniprot Accession | pdb | Depth (Å) | Absolute SASA (Å^2) | Half-Sphere Exposure (up) | Half-Sphere Exposure (down) | Coordination Number | Relative SASA | Estimated h_nho1 energy (DSSP) | Estimated h_ohn1 energy (DSSP) | Estimated h_nho2 energy (DSSP) | Estimated h_ohn2 energy (DSSP) | TCO (DSSP) | Kappa (DSSP) | Alpha (DSSP) | Phi (DSSP) | Psi (DSSP) | Structural Motif (DSSP) | Pocket Volume (Å^3) | Presence at Interface | Local Basic Content (Fraction of Local Neighbors) | Local Acidic Content (Fraction of Local Neighbors) | Local Polar Content (Fraction of Local Neighbors) | Local Cysteine Content (Fraction of Local Neighbors) | Local Structural Content (Fraction of Local Neighbors) | Local Aliphatic Content (Fraction of Local Neighbors) | Local Aromatic Content (Fraction of Local Neighbors) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GAPDH | P04406 | 6ynd | 7.2 | 0.0 | 25.0 | 24.0 | 49.0 | 0.0 | -2.5 | -2.2 | -0.6 | -0.5 | -0.9 | 37.5 | -135.7 | -134.8 | 154.6 | E | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.7 | 0.0 |
Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell
and Lawrence Lab