DrugMap: GAPDH (KB05)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   
KB05
KB05
   KB03
KB03
   KB02
KB02
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namepeptideinformation
bone_CAL72
bone_U2OS
bone_SAOS2
bone_SJSA1
bone_SKNMC
bone_A673
bone_SKES1
bone_TC71
bone_CAL78
CYS 152 IISNASCTTNCLAPLAK41154638
LTGMAFRVPTANVSVVDLTCR16122158922822
GAPDHDNA copy numberinformation1.279893711014241.31018008618090.996206001883251.090533150611921.015191651682471.115752166845881.230425976808520.6873311956478111.28485975164314
GAPDHDNA mutation statusinformation000000000
GAPDHRNA expressioninformation12.972620862058712.783816759320211.995731824905612.567457033318911.903580625348612.088953827817912.438843821924711.617100086875912.8587386774159
GAPDHCRISPR gene dependencyinformation0.980.981.001.000.961.001.001.00

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab