DrugMap: GAPDH (KB05)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   
KB05
KB05
   KB03
KB03
   KB02
KB02
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namepeptideinformation
breast_AU565
breast_CAL148
breast_ZR751
breast_MCF7
breast_HDQP1
breast_HCC1419
breast_CAL51
breast_MDAMB231
breast_BRX142JUNE
breast_BRX330FEB
breast_BRX50
breast_BRX82
breast_BRX394JUNE
breast_BRX29
breast_BRX330JAN
breast_BRX401
breast_BRX68
breast_BRX390
breast_BRX250MAY
breast_BRX211MAY
breast_HCC1937
breast_HCC1806
breast_CAMA1
breast_BT549
breast_MDAMB436
breast_MDAMB453
breast_DU4475
breast_CAL120
breast_MDAMB157
breast_HCC1143
breast_MDAMB468
breast_HS578T
breast_KPL1
breast_HCC1954
breast_HCC1395
breast_HCC1187
breast_HCC70
CYS 152 IISNASCTTNCLAPLAK-616-512131811201-19520182726082463338163318132-3721792461553164
LTGMAFRVPTANVSVVDLTCR-3-221-4-5-49-1336-17-115121624-20-3-15-23574915171231158-714-15-7-4-14-4
GAPDHDNA copy numberinformation1.129932118278341.033337494334651.608193695291880.8677283004280961.276143403697171.13355980518741.050586932073690.8978118387956851.31198894204080.9239377337222980.6303347450159470.9873841475357771.499404608033421.001460238250231.03682275237491.425489725592940.5575985258492480.8972476674048280.9226931038670220.8765916274093860.9062356019928481.328271259206561.082481333315081.433373268551441.01511334196657
GAPDHDNA mutation statusinformation0000000000000000000000000
GAPDHRNA expressioninformation12.661956197277311.369597346278712.36369674483911.722508717229611.18636189125311.878893899416911.968630797360912.396497752357212.531162115204710.497253084072310.883941501719111.403438163008312.694074892727511.869401059778111.602559691581112.07694917374110.695141274695411.137247340664711.673485757337812.632154591519111.728855861477612.685427736776312.110124385808711.637983303777911.7918547603173
GAPDHCRISPR gene dependencyinformation0.980.950.710.821.001.000.890.970.591.000.990.770.971.000.990.990.991.000.990.840.771.000.54

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab