DrugMap: GAPDH (KB05)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   
KB05
KB05
   KB03
KB03
   KB02
KB02
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namepeptideinformation
central_nervous_system_GB1
central_nervous_system_KNS81FD
central_nervous_system_LN229
central_nervous_system_T98G
central_nervous_system_DAOY
central_nervous_system_D283MED
central_nervous_system_PFSK1
central_nervous_system_ONS76
central_nervous_system_LN18
central_nervous_system_SF295
central_nervous_system_A172
central_nervous_system_GAMG
central_nervous_system_KNS42
central_nervous_system_SW1783
central_nervous_system_42MGBA
central_nervous_system_U87MG
central_nervous_system_U118MG
CYS 152 IISNASCTTNCLAPLAK-235-32561726361917172936
LTGMAFRVPTANVSVVDLTCR-3-5-13106293034-423-66163629
GAPDHDNA copy numberinformation1.203926865256730.9964179579653481.030458894902411.154632611491641.007547640507951.076235017320630.9542037641452280.8108342851713131.014557210174280.675274660276051.058855616458941.00833493864850.8954438520385580.907556274075541.048797841646721.07964277481318
GAPDHDNA mutation statusinformation0000000000000000
GAPDHRNA expressioninformation12.559687776678812.731064415315812.491853096329712.378511623253710.939579214314711.942294565550612.039604517953812.882146273282412.478592683866611.597121428789612.403784308638712.461811945058812.706258571151512.408488969843312.995731824905612.8054415999067
GAPDHCRISPR gene dependencyinformation0.991.001.001.001.000.650.980.981.000.971.000.751.000.991.00

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab