DrugMap: GAPDH (KB05)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   
KB05
KB05
   KB03
KB03
   KB02
KB02
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namepeptideinformation
kidney_KMRC1
kidney_CAKI1
kidney_KMRC20
kidney_786O
kidney_OSRC2
kidney_769P
kidney_RCC10RGB
kidney_G401
kidney_G402
kidney_KMRC3
kidney_A498
kidney_VMRCRCW
CYS 152 IISNASCTTNCLAPLAK29394526323737612
LTGMAFRVPTANVSVVDLTCR49-2-2-3-3-14142735-90
GAPDHDNA copy numberinformation0.9681583338467981.078065621956671.11270781133041.027376416118411.159889154308141.040599153136191.096695948504111.000045500717491.009573555213541.006332336366480.9293802743800391.03127327595034
GAPDHDNA mutation statusinformation000000000000
GAPDHRNA expressioninformation12.900206427698712.638458540774212.279697627604312.149715369704612.829346158390912.740919130185512.581836094120111.683608739149711.531332719995712.72619686792612.06403538790811.8742897945331
GAPDHCRISPR gene dependencyinformation0.960.711.001.000.990.960.980.991.001.00

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab