DrugMap: GAPDH (KB05)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   
KB05
KB05
   KB03
KB03
   KB02
KB02
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namepeptideinformation
liver_HLF
liver_HUH7
liver_JHH6
liver_JHH1
liver_SNU449
liver_SNU423
liver_HUH1
liver_JHH4
liver_SKHEP1
liver_JHH7
liver_HEP3B217
liver_HEPG2
CYS 152 IISNASCTTNCLAPLAK33363863632343036212455
LTGMAFRVPTANVSVVDLTCR1955712173016726231534
GAPDHDNA copy numberinformation1.06222147103171.041611307591781.233696564052431.209534289564740.914996833330790.7868532324550250.9701072542932971.124505220214881.285004795685961.035903426106271.015691921619940.955095837248408
GAPDHDNA mutation statusinformation000000000000
GAPDHRNA expressioninformation12.706280158849212.015240803332712.146441392222211.340629025951811.37471348450512.521183273707111.647053623553912.465540897245812.733502636347212.036723106005511.763668843654411.1660375162558
GAPDHCRISPR gene dependencyinformation0.980.650.941.001.001.001.000.970.981.000.67

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab