DrugMap: GAPDH (KB05)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   
KB05
KB05
   KB03
KB03
   KB02
KB02
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namepeptideinformation
ovary_TOV21G
ovary_OVTOKO
ovary_EFO21
ovary_OVK18
ovary_OV90
ovary_PEO1
ovary_OAW28
ovary_OVCAR4
ovary_SKOV3
ovary_OVISE
ovary_NIHOVCAR3
ovary_EFO27
ovary_OVKATE
ovary_OVCAR5
ovary_A2780
ovary_CAOV3
ovary_MCAS
ovary_OVCA429
ovary_OAW42
ovary_TYKNU
ovary_FUOV1
ovary_OV56
ovary_IGROV1
ovary_KURAMOCHI
ovary_OVCAR8
CYS 152 IISNASCTTNCLAPLAK134120332840281517372016181614-5377437452338251
LTGMAFRVPTANVSVVDLTCR120251118107-71833-625211-3-121014-85454-17131716
GAPDHDNA copy numberinformation0.9922613670398991.116068325073530.4508436049305681.021755094037671.10713117642441.248846736573190.9497377495834220.630854903126711.021244653627481.009006438316691.028526569712310.6330043062928270.938305301227491.040547252699221.432444583983920.8915301228476510.8683033717788920.890774844186581.476165761624271.069854857864691.060847395530690.8567615495041641.22486400733037
GAPDHDNA mutation statusinformation00000000000000000000000
GAPDHRNA expressioninformation12.461684070368712.75317495555399.1203415713721112.238613723883411.486281966251312.913674822459311.799362578568111.521796711411810.795877316795111.824720127350312.28987480070019.9262959947811111.818821807917611.596329545402913.312315746690111.862404896021512.280683788305912.220589939695712.438454006187411.590774157760612.486659072414610.649795066289412.8387705995569
GAPDHCRISPR gene dependencyinformation0.980.860.861.000.981.000.940.990.431.001.001.001.000.990.961.000.950.671.00

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab