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DrugMap cysteine engagement data for:
Probe:  KB05  KB03  KB02 | Download Table Download Statistics |
| name | peptide | peripheral_nervous_system_SKNAS | peripheral_nervous_system_KPNYN | peripheral_nervous_system_NB1 | peripheral_nervous_system_KELLY |
|---|---|---|---|---|---|
| CYS 152 | IISNASCTTNCLAPLAK | 21 | 28 | 18 | 36 |
| LTGMAFRVPTANVSVVDLTCR | 9 | 1 | 32 | 14 | |
| GAPDH | DNA copy number | 1.02981331981491 | 0.991778559953082 | 1.3287382709727 | 0.973343900107183 |
| GAPDH | DNA mutation status | 0 | 0 | 0 | 0 |
| GAPDH | RNA expression | 12.0205285921901 | 12.1381437825102 | 12.7034277862018 | 12.1297337887158 |
| GAPDH | CRISPR gene dependency | 1.00 | 0.94 | 0.97 | 1.00 |
Structural information (To highlight a cysteine, click a "CYS" button)
Cysteine | Gene | Uniprot Accession | pdb | Depth (Å) | Absolute SASA (Å^2) | Half-Sphere Exposure (up) | Half-Sphere Exposure (down) | Coordination Number | Relative SASA | Estimated h_nho1 energy (DSSP) | Estimated h_ohn1 energy (DSSP) | Estimated h_nho2 energy (DSSP) | Estimated h_ohn2 energy (DSSP) | TCO (DSSP) | Kappa (DSSP) | Alpha (DSSP) | Phi (DSSP) | Psi (DSSP) | Structural Motif (DSSP) | Pocket Volume (Å^3) | Presence at Interface | Local Basic Content (Fraction of Local Neighbors) | Local Acidic Content (Fraction of Local Neighbors) | Local Polar Content (Fraction of Local Neighbors) | Local Cysteine Content (Fraction of Local Neighbors) | Local Structural Content (Fraction of Local Neighbors) | Local Aliphatic Content (Fraction of Local Neighbors) | Local Aromatic Content (Fraction of Local Neighbors) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GAPDH | P04406 | 6ynd | 7.2 | 0.0 | 25.0 | 24.0 | 49.0 | 0.0 | -2.5 | -2.2 | -0.6 | -0.5 | -0.9 | 37.5 | -135.7 | -134.8 | 154.6 | E | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.7 | 0.0 |
Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell
and Lawrence Lab
