DrugMap cysteine engagement data for:
Probe: KB03 KB02 | Download Table Download Statistics |
name | peptide | soft_tissue_RKN | soft_tissue_A204 | soft_tissue_KYM1 | soft_tissue_HT1080 | soft_tissue_RD | soft_tissue_RH30 | soft_tissue_RH41 |
---|---|---|---|---|---|---|---|---|
CYS 152 | IISNASCTTNCLAPLAK | 34 | 41 | 24 | 28 | 35 | ||
LTGMAFRVPTANVSVVDLTCR | 11 | 5 | 37 | 15 | -8 | 6 | 4 | |
GAPDH | DNA copy number | 1.26796091498015 | 1.02899564931541 | 1.04171312563287 | 0.995907820211805 | 1.02158661917062 | 0.994413358818653 | 0.694741249968906 |
GAPDH | DNA mutation status | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
GAPDH | RNA expression | 13.2853733184317 | 13.1014997262522 | 11.7074885546584 | 12.8869920817866 | 12.1421070573025 | 12.8042722176473 | 10.7091699924758 |
GAPDH | CRISPR gene dependency | 0.96 | 0.86 | 1.00 | 1.00 | 0.95 |
Structural information (To highlight a cysteine, click a "CYS" button)
Cysteine | Gene | Uniprot Accession | pdb | Depth (Å) | Absolute SASA (Å^2) | Half-Sphere Exposure (up) | Half-Sphere Exposure (down) | Coordination Number | Relative SASA | Estimated h_nho1 energy (DSSP) | Estimated h_ohn1 energy (DSSP) | Estimated h_nho2 energy (DSSP) | Estimated h_ohn2 energy (DSSP) | TCO (DSSP) | Kappa (DSSP) | Alpha (DSSP) | Phi (DSSP) | Psi (DSSP) | Structural Motif (DSSP) | Pocket Volume (Å^3) | Presence at Interface | Local Basic Content (Fraction of Local Neighbors) | Local Acidic Content (Fraction of Local Neighbors) | Local Polar Content (Fraction of Local Neighbors) | Local Cysteine Content (Fraction of Local Neighbors) | Local Structural Content (Fraction of Local Neighbors) | Local Aliphatic Content (Fraction of Local Neighbors) | Local Aromatic Content (Fraction of Local Neighbors) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GAPDH | P04406 | 6ynd | 7.2 | 0.0 | 25.0 | 24.0 | 49.0 | 0.0 | -2.5 | -2.2 | -0.6 | -0.5 | -0.9 | 37.5 | -135.7 | -134.8 | 154.6 | E | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.7 | 0.0 |
Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell
and Lawrence Lab