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DrugMap cysteine engagement data for:
Probe:  KB05  KB03  KB02 | Download Table Download Statistics |
| name | peptide | thyroid_8505C | thyroid_8305C | thyroid_FTC133 | thyroid_CAL62 |
|---|---|---|---|---|---|
| CYS 152 | IISNASCTTNCLAPLAK | 25 | 8 | 21 | 20 |
| LTGMAFRVPTANVSVVDLTCR | -6 | -17 | -31 | -9 | |
| GAPDH | DNA copy number | 0.975292265533584 | 0.843037867563065 | 0.870775900642935 | 1.00131059475486 |
| GAPDH | DNA mutation status | 2 | 0 | 0 | 0 |
| GAPDH | RNA expression | 12.8091250015223 | 12.7589726883427 | 12.7361905009609 | 11.712011045839 |
| GAPDH | CRISPR gene dependency | 1.00 | 1.00 | 1.00 | 1.00 |
Structural information (To highlight a cysteine, click a "CYS" button)
Cysteine | Gene | Uniprot Accession | pdb | Depth (Å) | Absolute SASA (Å^2) | Half-Sphere Exposure (up) | Half-Sphere Exposure (down) | Coordination Number | Relative SASA | Estimated h_nho1 energy (DSSP) | Estimated h_ohn1 energy (DSSP) | Estimated h_nho2 energy (DSSP) | Estimated h_ohn2 energy (DSSP) | TCO (DSSP) | Kappa (DSSP) | Alpha (DSSP) | Phi (DSSP) | Psi (DSSP) | Structural Motif (DSSP) | Pocket Volume (Å^3) | Presence at Interface | Local Basic Content (Fraction of Local Neighbors) | Local Acidic Content (Fraction of Local Neighbors) | Local Polar Content (Fraction of Local Neighbors) | Local Cysteine Content (Fraction of Local Neighbors) | Local Structural Content (Fraction of Local Neighbors) | Local Aliphatic Content (Fraction of Local Neighbors) | Local Aromatic Content (Fraction of Local Neighbors) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GAPDH | P04406 | 6ynd | 7.2 | 0.0 | 25.0 | 24.0 | 49.0 | 0.0 | -2.5 | -2.2 | -0.6 | -0.5 | -0.9 | 37.5 | -135.7 | -134.8 | 154.6 | E | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.7 | 0.0 |
Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell
and Lawrence Lab
