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DrugMap cysteine engagement data for:
Probe:      ![]() KB03 ![]() KB02  | Download Table Download Statistics  | 
| name | peptide | urinary_tract_KU1919  | urinary_tract_HT1376  | urinary_tract_UMUC3  | urinary_tract_J82  | urinary_tract_RT112  | urinary_tract_TCCSUP  | urinary_tract_HT1197  | urinary_tract_T24  | 
|---|---|---|---|---|---|---|---|---|---|
| CYS 152 | IISNASCTTNCLAPLAK | 23 | 15 | 37 | 26 | 16 | 12 | 16 | 26 | 
| LTGMAFRVPTANVSVVDLTCR | -8 | -15 | -4 | 2 | 1 | 1 | -15 | 5 | |
| GAPDH | DNA copy number | 1.22148377932462 | 0.864183207512248 | 1.19417622717254 | 0.983755497671894 | 1.03140351565676 | 0.97792550710714 | 1.10072219191922 | 1.10410888924479 | 
| GAPDH | DNA mutation status | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 
| GAPDH | RNA expression | 11.9768504860683 | 11.4551216935515 | 13.1240889930299 | 12.5825654112096 | 12.428072233133 | 11.3731370358021 | 12.1360298493856 | 13.1561304909907 | 
| GAPDH | CRISPR gene dependency | 1.00 | 0.24 | 1.00 | 0.99 | 0.91 | 0.99 | 0.59 | 0.99 | 
Structural information (To highlight a cysteine, click a "CYS" button)
Cysteine  | Gene  | Uniprot Accession  | pdb  | Depth (Å)  | Absolute SASA (Å^2)  | Half-Sphere Exposure (up)  | Half-Sphere Exposure (down)  | Coordination Number  | Relative SASA  | Estimated h_nho1 energy (DSSP)  | Estimated h_ohn1 energy (DSSP)  | Estimated h_nho2 energy (DSSP)  | Estimated h_ohn2 energy (DSSP)  | TCO (DSSP)  | Kappa (DSSP)  | Alpha (DSSP)  | Phi (DSSP)  | Psi (DSSP)  | Structural Motif (DSSP)  | Pocket Volume (Å^3)  | Presence at Interface  | Local Basic Content (Fraction of Local Neighbors)  | Local Acidic Content (Fraction of Local Neighbors)  | Local Polar Content (Fraction of Local Neighbors)  | Local Cysteine Content (Fraction of Local Neighbors)  | Local Structural Content (Fraction of Local Neighbors)  | Local Aliphatic Content (Fraction of Local Neighbors)  | Local Aromatic Content (Fraction of Local Neighbors)  | 
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GAPDH | P04406 | 6ynd | 7.2 | 0.0 | 25.0 | 24.0 | 49.0 | 0.0 | -2.5 | -2.2 | -0.6 | -0.5 | -0.9 | 37.5 | -135.7 | -134.8 | 154.6 | E | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.7 | 0.0 | 
Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell
and Lawrence Lab