DrugMap: PHGDH (KB03)

DrugMap cysteine engagement data for:

PHGDH
Gene: 
   
Probe:   KB05
KB05
   
KB03
KB03
   KB02
KB02
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namepeptideinformation
skin_A375
skin_RPMI7951
skin_SKMEL2
skin_HMCB
skin_SKMEL3
skin_G361
skin_UACC257
skin_SKMEL30
skin_MEWO
skin_UACC62
skin_LOXIMVI
skin_WM2664
ovary_TOV21G
ovary_OVTOKO
ovary_EFO21
ovary_OVK18
ovary_OV90
ovary_PEO1
ovary_OAW28
ovary_OVCAR4
ovary_SKOV3
ovary_OVISE
ovary_NIHOVCAR3
ovary_EFO27
bile_duct_ICC21
bile_duct_ICC137
bile_duct_ICC10
bile_duct_ICC106
bile_duct_SNU245
bile_duct_ICC11
bile_duct_ICC108
bile_duct_ICC24
bile_duct_TGBC1TKB
bile_duct_ICC20
bile_duct_ICC8
bile_duct_KMCH1
ovary_OVKATE
ovary_OVCAR5
ovary_A2780
ovary_CAOV3
ovary_MCAS
ovary_OVCA429
ovary_OAW42
soft_tissue_RKN
bile_duct_ICC26
bile_duct_TFK1
bile_duct_ICC3
bile_duct_ICC18
lung_MGH0061
lung_NCIH3122
lung_MGH0651
lung_MGH0261
lung_MGH0732
lung_MGH0653
lung_MGH9153
lung_MGH0752
lung_MGH97967
lung_MGH9521R
lung_MGH92431
lung_MGH91621
skin_COLO792
skin_MELJUSO
skin_COLO679
skin_A2058
skin_SKMEL28
skin_IGR1
skin_HS944T
skin_IGR37
skin_RVH421
skin_IPC298
skin_WM793B
breast_AU565
breast_CAL148
breast_ZR751
breast_MCF7
breast_HDQP1
breast_HCC1419
breast_CAL51
breast_MDAMB231
breast_BRX142JUNE
breast_BRX330FEB
breast_BRX50
breast_BRX82
breast_BRX394JUNE
breast_BRX29
breast_BRX330JAN
breast_BRX401
breast_BRX68
breast_BRX390
breast_BRX250MAY
breast_BRX211MAY
skin_MEL182
skin_MEL167
skin_IGR39
fibroblast_HS839T
blood_CMK
blood_THP1
blood_U937
blood_MONOMAC1
blood_KASUMI1
blood_MOLM13
blood_P31FUJ
blood_OCIAML5
bile_duct_SNU1079
bile_duct_RBE
bile_duct_YSCCC
bile_duct_ETK1
bile_duct_ECC2
bile_duct_EGI1
bile_duct_SNU869
bile_duct_SNU1196
bile_duct_OCUG1
bile_duct_GB2
bile_duct_SNU308
bile_duct_G415
lymphocyte_HT
lymphocyte_A3KAW
lymphocyte_RL
lymphocyte_KARPAS422
lung_MGH8022
lung_MGH8021
lung_MGH8091
lung_MGH9201
lung_MGH1701
lung_MGH100151
lung_MGH1542
lung_MGH100164
bile_duct_CCSW1
bile_duct_CCLP1
bile_duct_SG231
bile_duct_HUCCT1
skin_CHL1
skin_COLO829
skin_A375S2
skin_A101D
skin_SKMEL24
skin_SH4
skin_HS936T
lung_MGH90921
plasma_cell_KMS12BM
plasma_cell_KMS11
plasma_cell_KMS27
plasma_cell_RPMI8226
ovary_TYKNU
ovary_FUOV1
lung_ABC1
lung_A549
lung_HCC15
lung_CALU6
pancreas_CFPAC1
pancreas_BXPC3
pancreas_KP4
pancreas_HUPT4
breast_HCC1937
breast_HCC1806
breast_CAMA1
breast_BT549
breast_MDAMB436
lung_MGH1543
lung_MGH1541
lung_MGH8222
lung_MGH1904
bile_duct_TKKK
bile_duct_SNU478
bile_duct_HUH28
bile_duct_ICC12
lung_NCIH1703
lung_LU65
lung_NCIH1155
liver_HLF
liver_HUH7
liver_JHH6
liver_JHH1
bile_duct_HKGZCC
bile_duct_TGBC52TKB
bile_duct_ICC9
bile_duct_MG984
bile_duct_OZ
bile_duct_SSP25
bile_duct_ICC19
bile_duct_ICC4
brain_MGG75
brain_MGG23
brain_MGG123
kidney_KMRC1
kidney_CAKI1
kidney_KMRC20
kidney_786O
colorectal_SW403
colorectal_RKO
colorectal_MDST8
colorectal_SW948
uterus_HEC1
uterus_AN3CA
uterus_MFE296
uterus_RL952
lung_NCIH2172
lung_HCC44
lung_CORL23
lung_NCIH1299
colorectal_HCT15
colorectal_LS513
colorectal_HT115
colorectal_HT29
upper_aerodigestive_DETROIT562
upper_aerodigestive_BICR22
upper_aerodigestive_CAL27
upper_aerodigestive_HSC3
ovary_OV56
ovary_IGROV1
pancreas_SW1990
pancreas_DANG
pancreas_HUPT3
pancreas_PATU8988T
prostate_LNCAPCLONEFGC
prostate_DU145
prostate_VCAP
prostate_PC3
lung_NCIH1666
lung_NCIH23
lung_SW1573
lung_NCIH1944
lung_PC14
lung_HCC827
lung_LUDLU1
lung_NCIH1975
esophagus_KYSE150
esophagus_TE11
esophagus_KYSE30
esophagus_KYSE510
bone_CAL72
bone_U2OS
bone_SAOS2
bone_SJSA1
uterus_MFE280
cervix_SISO
uterus_ISHIKAWAHERAKLIO02ER
uterus_SNGM
lung_NCIH2170
lung_NCIH2122
lung_NCIH1792
blood_MOLM16
blood_MONOMAC6
blood_JURLMK1
blood_NOMO1
blood_KASUMI2
blood_697
blood_REH
blood_JM1
skin_WM115
skin_C32
skin_COLO853
urinary_tract_KU1919
urinary_tract_HT1376
urinary_tract_UMUC3
urinary_tract_J82
urinary_tract_RT112
urinary_tract_TCCSUP
urinary_tract_HT1197
urinary_tract_T24
breast_MDAMB453
breast_DU4475
breast_CAL120
lung_NCIH1048
lung_SW1271
lung_NCIH446
lung_NCIH2286
thyroid_8505C
thyroid_8305C
thyroid_FTC133
thyroid_CAL62
breast_MDAMB157
breast_HCC1143
breast_MDAMB468
central_nervous_system_GB1
central_nervous_system_KNS81FD
central_nervous_system_LN229
central_nervous_system_T98G
liver_SNU449
liver_SNU423
liver_HUH1
liver_JHH4
liver_SKHEP1
liver_JHH7
liver_HEP3B217
liver_HEPG2
skin_COLO800
skin_SKMEL5
esophagus_KYSE180
esophagus_KYSE410
esophagus_TE4
esophagus_TE1
ovary_KURAMOCHI
ovary_OVCAR8
pancreas_PANC0403
pancreas_MIAPACA2
pancreas_SUIT2
blood_MV411
blood_KO52
blood_TF1
blood_OCIAML2
cervix_HT3
cervix_CASKI
cervix_C4II
cervix_DOTC24510
lymphocyte_SUDHL4
blood_NALM6
lymphocyte_JEKO1
blood_JVM3
skin_A431
esophagus_OE33
esophagus_TE10
lymphocyte_OCILY3
blood_MEC1
blood_HG3
lymphocyte_SUDHL6
breast_HS578T
breast_KPL1
breast_HCC1954
breast_HCC1395
colorectal_COLO678
colorectal_LS123
colorectal_SW1116
colorectal_CCK81
bone_SKNMC
bone_A673
bone_SKES1
bone_TC71
central_nervous_system_DAOY
central_nervous_system_D283MED
central_nervous_system_PFSK1
central_nervous_system_ONS76
uterus_SKN
uterus_MFE319
kidney_OSRC2
kidney_769P
kidney_RCC10RGB
lung_NCIH1793
lung_NCIH1650
lung_CALU1
lung_NCIH358
skin_WM1552C
skin_MELHO
lung_NCIH2052
lung_MSTO211H
lung_CORL88
lung_SBC5
gastric_KATOIII
gastric_MKN45
gastric_OCUM1
gastric_SNU1
peripheral_nervous_system_SKNAS
peripheral_nervous_system_KPNYN
peripheral_nervous_system_NB1
peripheral_nervous_system_KELLY
kidney_G401
soft_tissue_A204
soft_tissue_KYM1
kidney_G402
lung_NCIH196
lung_NCIH146
lung_SHP77
lung_NCIH82
gastric_HGC27
gastric_AGS
gastric_NCIN87
gastric_IM95
upper_aerodigestive_FADU
upper_aerodigestive_CAL33
upper_aerodigestive_SCC25
upper_aerodigestive_HSC4
cervix_SW756
bone_CAL78
lymphocyte_KARPAS299
gastric_MKN1
plasma_cell_OPM2
plasma_cell_SKMM2
soft_tissue_HT1080
central_nervous_system_LN18
breast_HCC1187
breast_HCC70
blood_HEL9217
blood_HEL
blood_EOL1
gastric_SNU5
gastric_NUGC3
soft_tissue_RD
soft_tissue_RH30
soft_tissue_RH41
lymphocyte_REC1
esophagus_TE8
pancreas_PANC1
kidney_KMRC3
lung_NCIH2291
lymphocyte_L428
unknown_HDMYZ
skin_MCC13
skin_MCC26
prostate_22RV1
kidney_A498
kidney_VMRCRCW
colorectal_SW837
colorectal_LS180
colorectal_SW620
colorectal_COLO320
central_nervous_system_SF295
central_nervous_system_A172
central_nervous_system_GAMG
central_nervous_system_KNS42
blood_JURKAT
blood_PF382
lymphocyte_DEL
blood_SUPT1
central_nervous_system_SW1783
central_nervous_system_42MGBA
central_nervous_system_U87MG
central_nervous_system_U118MG
VLISDSLDPCCR373345322141413672-10222620137-42142529835729404220-444362935
EELIAELQDCEGLIVR-21421133-4216-52811359-72226-9-200-16-173923607437163418284928-2111499338834435-2143612913-3-9-23-14-4-1576-1321-23-3715-35-25-261812-8-384-58-4612-30-3831-34-17-36-4133-14-19421-3251-6-172115176827-129-1536382817396083520417053-42-612-32-12-5130-3704146-923395342-3735-17452643-153751252011174151277392869-19-313980440601245-13-121850-33-35-3640-18-18672453-23392188411-7-26-9503713818-10-2417-17-9-316378206548835-202186117162312731918-516254-1143301617-2513053473841183625132647-10-4351731162793626553944-7-6120242832564654-181416-8324-3977194055-22415-7-5-2-15-2120-8-26-4911-231840-49-3-17-11312-547202925-727136155-24-72715181010-4-164178-2556-351930-6-20-21-242-28-151-13-13-23-1-351810-12-20-13-638-1911-27-21-38101220643053-9-2-27-36458-143
*
VVNCAHGGIVDEGALLR2033555477838383221565765193548793945394552453919395144446042464136355331243340462912322726-8453638404535314129382554354540-13-32218-116734312344148642231966031412228401731284475322773562373931-415323940403031622935331118273834302837252650353945442743-10357125442-1417-8251137181630241627371227292919-520143145484722213418326618382824124122304141293728433722243423331046403149592517119343225533727463230151917132011192731231310-3912263829292032393530927912212182911-824312727411261517-2232719262729232928452276027484572416304618603022371430344527-122519-628314328173415326442222
ALQSGQCAGAALDVFTEEPPR40343335387-2020394037352415321027411-1351536750402230292652142242124944283533343013816298324217152925182218312482332272020119191812422426203715371920263530362731343824343024276211520278233164711532061154035354331-427132311137563723324956371539938213327361818421833362210141932311086924-7-42623430271517-207531810731110282052528253322026133221114141038172255254236-1119-391128222035242024291320463325-922152940344123113330483340361630222629255223219262517222726303211171219189384030403123473741193318-4312451516422141361042292489-31161522132430325371120431-51811251641253731961313192002023017162142573018421-3271925-6658-162412972484634631882021161214271821142632216372511931512372821
ALVDHENVISCPHLGASTK42404848-22215042532925545811264053286347574665501624-51520302933205121445030504136611203239341159297045816274531254126234828434229374553433816335428365541624571376354420453942534940532832584833464154422753403638364841377964373743574341442548355055412533444148472226565124366775442763376456714262774748454665554531695464591533666144575062-6534152504474413129323201417-104942-15-162551716-1320251652193534443042391754425618554421564351924112952373959424757124917394135461941284036542449524953274530465159255718685261404543476452552924366948524847485155604859402238341162555856595861594647484114554222274150524650284419414137273240243321423315445926423843372952523048455445374945342740163642284826564052324041632100372521-134223229332034411529163917574038323230162655515430363621462637373324474552523332112544545654
CGEEIAVQFVDMVK18439206173813281921613183134343239472850205624935025141545352117211828-1392017271418621312211211122372253-10711351115335540172619165438123738455836-82192311131528192253313015274033703132334226153120349693349152820221320171920-5331222937414035372646644440443121384953323922284030274543455073424313342341739322825232161127231628663395748516032302930383972044332441483734474852382832433329403825583949193034293423143726384033243922292043152840352222302334236122620222721373243382234271434258209733132814382216309281439422619351313274802313271229152717163220281414293120122512271667
CYS 369 NAGNCLSPAVIVGLLK82838690358279859090817084707987938783878579849495888683756463914772626858292888753729345808586749293727686918692911419819094948893699142969784879192895776918294889484748743879792968492937770397262869329816476568878877371879273889258457490909391838575818992949694868594819586849497828597949592929593867760798389879494749094899389978555948563827554785837490848839858974899269937879879071786736728458828082867585919388888572571983757587868181818988839267839181857492878788868693787589839093769184817969727577886377926479638789768565589292838987766888777075687991808679898487867269747190809080828985459192746981805687573480757788867276908587909164828679878288928973817985238092878592397992887893889484908327899394919186658486858588586858688857384708391909172868456655278776883548086899296938875848789878883758785
PHGDHDNA copy numberinformation1.085772251334981.092920159847361.620455275713311.002051495749891.080103311233511.017717980098041.148831012722331.254580533078561.005584265901351.079958918335980.9598866529638311.401488690084260.9940393645767360.9180701862302141.311810973483511.005334827288451.020759745498821.093017901454811.364023341352541.045274847947261.051586540132131.234485887732251.014411266694691.137794054032350.7404483038167490.9038756003199681.154885455681031.471040021109761.394665581337090.7518136560901291.170723458737681.016647959707220.8895279660239061.028528099081451.25139808000141.098560986920391.094916521386091.312309083826451.124570182338710.9717824663394120.8764823489977760.9510183128181690.8217672500709940.9734356595153321.741314403047890.9755984184295191.12861515416431.024817858731680.938782585532071.864496278599631.202926606263170.9858614656556121.263677442309541.029974477006131.021052903244521.131977968616111.025515721723411.19837278425010.9304050706346091.004754809678311.050309205442151.326599624015811.143345669819521.000774207623911.004524071229570.9741203660336810.9973449476074480.9935484899007911.254837300551811.072755815289211.002205683520760.9948841029528121.015102732583321.036134998706741.054706959160551.135894414564220.9849433980317321.196586147841471.096751320479431.012689318661031.006853200372471.01506130619950.981917758150511.414593418942341.012874941681280.8259652724319970.9520522403859740.7478657453784241.159204796490571.021582559770891.263493058713520.9788454084656160.8898225352388060.7957823498833450.9846505337566161.321889394800721.16534300797591.053753018885610.9639753193624390.8127660331806911.080702627655750.9215365266461351.088473802197241.16226849955190.9618467335203580.9450760087674811.364938945319440.9421821085747551.76997801136261.244868623064141.514189832803760.7381116765713981.042185794197421.221564885552171.128677559530871.249321170773030.9425509374451380.9903345954179591.176106057908230.8801257326558171.05903086201430.8503451107639330.7092003431743841.090915092141270.9946763586869181.107141892134570.9637443313089250.9026943620081740.9840026884646240.9683822415736631.076842356646141.06819267125461.005015186864250.8228077708530161.099143145384511.116759016693420.9875338292061121.029956700294411.034520875382451.493563369420891.321174325782691.003045207107840.9400162875497940.9991432545406120.9582846021692361.028582137791681.067944606381630.8299800998017361.03850090757511.038303864243231.109813323449411.011004149567781.054069205904351.232882854633880.9697181311786831.040204548618630.7704967777688321.047756152608540.9455754432895311.055421761156511.041036008975781.825350844950771.109211851560560.9709460765522931.346485310903981.09809359653180.679499428337720.8958897032662831.20484895510961.129591651727851.040230235908770.8562063977182871.748798491185651.261111169993781.199790676457011.037946275307911.495347029759431.1333611798771.032562378480841.01551807119771.1038259987340.9348623025743081.381356509074171.163284446208230.947283775470681.020225312734820.9901260223295761.003601484106211.002505672153131.006464418279760.9348885327541831.73212548606840.9955887646636821.881187332082891.001514794414451.114572080214410.9876473400804931.036170352504170.9999920000221811.024211816839081.01685987854381.013561648080021.038738522422021.159815127134111.023241239428330.8729607043297241.192686096242021.059632150367711.026887473392141.016005813978670.9925946041610920.9295593300525841.074683275122260.923596794989811.258636674639071.358087318298730.9999125026534541.072564875984950.9382938255697760.8959378129683570.7814220428649050.9696662563680031.067271265814541.004310420063840.7963255934324310.9530584367113571.073784868635741.248510819964491.225314923790971.056233443964521.243437880428781.74074952247481.110766141636881.505609912930620.8149100592777971.067543134394711.166442762258540.9864631107287460.9951382196355730.9259814629438210.9923677955163721.042929295663470.9646543765358041.024921601978192.021480742699030.9748967742832540.9998870044253981.082391084767660.9985277519706391.124125241446321.061449382029961.05662594366491.229804068085910.9714281517554321.035137746654640.9927304081585461.137545848357951.281880058931511.016529116394961.385691421576550.9056596993189190.7948203757166550.8154250266859990.6285336598363571.014194650637071.235736926576441.266769536417651.117282881078711.493106844295781.039982114792831.113232566319691.27361103582441.150165063028921.046038415421981.125490745325071.046009020586540.9149033754112280.9706252759745941.063926412154351.106232909446310.9618574387774091.171848195256340.7909259106926951.106098505718060.996905326273521.091939349106910.9284379063476060.6916810476189760.9687807698440420.9965895406319541.044406564825471.016571089748471.223985938324251.295678484153321.002118052500881.027967944510141.032753564006291.002824259022851.237826075460171.046324657693531.114942921531961.17358532194431.060755763884071.010331731992041.037476971346621.021742407012361.323912903691720.9911637272156651.153923848904491.182138226612540.9739730888672291.363990320449460.984799431821681.21926610971430.4060098675065011.020759745498820.9954855853257980.8581088870749291.306364434687791.434264506581471.109963591090651.137219143928670.9803649619048841.036905283268780.9309988414359831.209314644268761.033347211372991.080123864561821.186121985008740.8909849301744971.391883066081171.006533226153651.03481366591070.9607863554823541.190894797426571.014813782578011.163254003686010.9924100707113430.8971740382823110.9753713772548961.032652856311461.039768958107540.9498448185508241.226653987880781.024089316471270.8770803140706281.077167943346090.9454417938056651.012377645837461.049464437367580.9733836454173181.011197621251230.9164818050585161.371154834636621.379771101947361.08504576073436
PHGDHDNA mutation statusinformation000000000001000000000000000000000000000000000000000000000002000000000000000000000000000000000000000002000000000000000000000000100000001000000000000000000000000020000000000000000000000000000000000000000000000000000000000000000000000000000000000010000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
PHGDHRNA expressioninformation7.920114619846548.221683781010975.661920579135098.826834455761230.5753123306874376.88019572894317.922673592849457.972290573087276.875288598222696.265661924521890.378511623253737.372778017062046.752882366273092.432959407276118.352264173258327.532394890192529.028320504557486.168120504595568.39908562357245.020146573111787.555969494599538.247737672658936.43179008337886.582556003014066.094447221699917.568716188731735.543186524565175.932155684432062.480265122054464.77715666600450.02856915219677096.657211248443795.105594275795198.960465374102558.23194114830877.156740421183135.816599706534918.085445902194277.354910511586797.558344175692540.9335726382610240.6870606883398926.923386915504718.083426139437467.606738317417597.939344132834487.369815424283918.524541715035858.970336013042138.521207816223996.579391370642747.146186791490745.233811384293166.919101679559396.041111535369156.955475553181578.476746203939472.289834465177515.884842093799467.730775796512056.192588721566647.187055089968068.399641089691067.297466573763216.329123596291578.138527801422279.138834942971377.751811819862120.4114262457264657.450303989824126.305970520984395.488643539853785.80400191517938.064473328753428.188391033340694.721919445551546.522777669524586.492654371018917.185767455710633.933572638261026.063718640152257.174226629755462.032100843167028.152842542773895.525755692829497.297007949274854.912170802949955.981624360696367.033533126726696.597382189348688.817751150339046.927540949589477.039577103060685.343407822297819.123060877452053.217230716220677.15096578355657.560179957764185.836681593327125.853496703702326.724377421606226.660067222930645.69069644397776.500483401473127.547434405106676.149137401227996.254556251909497.029011086659075.980025300238735.124741692419658.115355831721112.729008870337866.65148228215093.52982094652877.792985459684668.266177482425780.4646682670034448.361154241298287.618238655595457.637059538410858.406545173427955.673556423990147.625124341875115.143230134776890.05658352836636755.70459534763246.731590571594451.794935662803546.147510224920287.654206377944290.9107326619029134.605849867194985.015693807105155.718909554379234.702657543390916.989593184938777.506049668250327.760952755545857.430117974892036.515226745956184.759688488427290.6229303509201776.242030801922737.403352945190781.516015147003674.381283372503785.356848079236526.227086416874645.034303767768046.396433531250996.283366212949926.899296494640176.198886990956936.011450911735756.909173056285013.682573297347586.379378367071268.693939906569787.016251155012755.792855352362494.914564523493944.232660756790277.547203024756935.274261661257057.510249887491494.743622676067666.069530325162315.225737653466066.577730931490087.066950243924635.826039958896197.44633895085759.402820219756628.040015678847888.592083233653895.580447019598668.150610446200114.161887682376898.03595375655785.56772796330487.132885253625167.008876768394265.965322548367257.8819704499968.637928981009018.558267634055744.81711157279577.913188619508898.678916986679848.265005493343737.087250664613316.976134472831658.173177415120428.770498720892897.078631181233537.04581425618856.612942196304676.847245307141818.588039971083837.784045870231576.668317719915727.106222672919120.8237493603082737.560409266362128.629283754853660.6322682154995137.800770504427966.65735418152376.64774621720817.206330647871054.343407822297817.46066066460766.713283400230746.364047083607328.652092066118297.797726364623287.654922391180936.829595899177515.368768349090335.929080835242586.44327511176586.965899695648987.467034879870368.833649127594985.73118324157227.177917792195848.149086579738225.300855871268766.870611313044557.403864176606797.395919659458967.587364990936467.228337711981387.551977360180865.35473423997065.9701634246617.498490232908616.231125157879058.365053833930815.207892851641337.273142859308083.517275693209586.093602428795736.611024797307355.761285273361620.9030382701129128.466341619573086.189824558880028.019201509567398.382926582571243.937344392150235.58946389295618.144352338662616.88910844192410.6780719051126388.009436755608098.953090596217396.090218301653326.949885059226938.995908446117226.401732849522625.101397952182535.920055054806976.524972598286637.452941307971218.784405828168229.328405658958578.861955364144877.454422683499888.483815777264267.156538193114277.552745936748456.835292504380055.757556688939453.749534267669263.446256229889566.619266268489197.305879346778857.042316016897115.670443812122817.159568641730767.281976377858755.80735492205767.190516096215567.440038600494738.6469906440040.5655971758542256.15866017534651.811471030529848.362601387531131.144046369616717.803162444415898.934840812038367.937874005084947.589988141685427.236205581531697.834913429701040.9927684307689248.525325043433486.334317984693448.095080491901417.812819073781658.487277313213780.4329594072761066.221490455042066.666472568842078.020535537055295.626731150672793.902073579310748.547472964890736.124534928529528.216260837165060.4854268271702427.478001055837930.847996906554958.49892896631956.460906348207256.866660750819998.168571840448118.801837670323627.579391370642748.735522177296548.482202926295953.69153416491926.07232021603277.768779809908547.802645604128825.087462841250345.79675347697375.757289992378774.226508529808684.831877241191673.861955364144877.972290573087278.386509204077949.471858079638417.821455119102467.645586385913617.543031820255247.124948426681086.023698917266417.917312401095034.060047383669948.861024853261315.986865972329115.694880192799195.279842693520356.509379148914698.826389591421948.929643076027848.363871924857537.92582144355255.296457407371248.253563880693028.656389108310786.90436366757948
PHGDHCRISPR gene dependencyinformation0.070.030.040.030.290.060.060.010.160.020.000.180.050.050.010.070.470.170.010.050.020.390.020.090.140.030.160.310.080.050.020.040.170.050.040.040.060.160.030.090.140.090.350.070.020.170.010.190.010.030.140.060.070.190.050.020.080.050.040.180.020.030.080.100.040.000.020.020.030.080.040.080.020.070.150.010.050.050.020.030.130.040.040.030.120.120.110.070.040.050.030.010.050.610.040.060.050.020.240.010.020.160.020.040.030.070.040.020.140.110.120.010.050.040.130.430.020.010.090.110.010.130.020.270.120.120.160.040.150.170.010.070.030.030.140.070.020.320.050.050.160.080.050.040.080.120.040.060.020.040.080.010.060.090.030.110.020.080.140.040.050.000.020.020.010.010.000.060.020.010.740.370.040.080.060.020.010.030.220.020.050.010.010.070.030.110.050.050.060.020.100.030.170.020.160.080.020.210.000.030.030.030.060.060.050.030.010.110.070.120.010.070.010.210.040.020.010.020.120.380.020.140.010.010.080.010.260.160.080.020.010.050.020.140.050.100.290.010.080.220.030.020.110.090.040.050.040.030.010.370.200.050.060.010.010.150.170.010.050.030.190.060.010.040.040.030.010.030.090.030.030.080.050.020.120.040.010.080.100.010.010.170.060.140.140.010.040.060.020.010.180.060.060.050.070.050.000.010.050.000.080.020.040.040.180.060.020.060.030.070.020.040.10

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
PHGDHO431756rj32.418.010.013.023.00.1-0.2-2.2-0.2-0.20.887.161.4-59.3-31.4H0.00.00.20.20.00.20.20.20.0
PHGDHO431756rj34.40.021.010.031.00.0-1.8-0.2-0.1-0.2-0.940.9-178.6-107.6129.0N/A0.00.00.30.30.00.00.20.20.0
PHGDHO431756rj33.013.925.023.048.00.1-0.6-0.1-0.4-0.10.066.071.7-110.620.1N/A0.00.00.00.20.40.00.00.40.0
PHGDHO431756rj33.41.124.013.037.00.0-2.2-0.3-0.2-0.2-1.075.4-165.5-110.3124.0E0.00.00.00.00.10.00.40.50.0
PHGDHO431756rj37.20.027.023.050.00.2-1.6-2.0-0.3-0.1-1.041.0-106.1-141.2156.0N/A0.00.00.00.20.20.00.20.40.0
PHGDHO431756rj33.01.326.015.041.00.0-2.7-2.2-0.2-0.20.9109.152.4-63.2-41.6H0.00.00.10.10.20.00.30.20.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab