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DrugMap cysteine engagement data for:
Probe:  KB05  KB03  KB02 | Download Table Download Statistics |
| name | peptide | liver_HLF | liver_HUH7 | liver_JHH6 | liver_JHH1 | liver_SNU449 | liver_SNU423 | liver_HUH1 | liver_JHH4 | liver_SKHEP1 | liver_JHH7 | liver_HEP3B217 | liver_HEPG2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CYS 152 | IISNASCTTNCLAPLAK | 39 | 6 | 62 | 23 | 39 | 42 | 49 | 45 | 45 | 26 | 28 | 54 |
| LTGMAFRVPTANVSVVDLTCR | 18 | 38 | -6 | -2 | 2 | 9 | 5 | -4 | 10 | -2 | 3 | 7 | |
| GAPDH | DNA copy number | 1.0622214710317 | 1.04161130759178 | 1.23369656405243 | 1.20953428956474 | 0.91499683333079 | 0.786853232455025 | 0.970107254293297 | 1.12450522021488 | 1.28500479568596 | 1.03590342610627 | 1.01569192161994 | 0.955095837248408 |
| GAPDH | DNA mutation status | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| GAPDH | RNA expression | 12.7062801588492 | 12.0152408033327 | 12.1464413922222 | 11.3406290259518 | 11.374713484505 | 12.5211832737071 | 11.6470536235539 | 12.4655408972458 | 12.7335026363472 | 12.0367231060055 | 11.7636688436544 | 11.1660375162558 |
| GAPDH | CRISPR gene dependency | 0.98 | 0.65 | 0.94 | 1.00 | 1.00 | 1.00 | 1.00 | 0.97 | 0.98 | 1.00 | 0.67 |
Structural information (To highlight a cysteine, click a "CYS" button)
Cysteine | Gene | Uniprot Accession | pdb | Depth (Å) | Absolute SASA (Å^2) | Half-Sphere Exposure (up) | Half-Sphere Exposure (down) | Coordination Number | Relative SASA | Estimated h_nho1 energy (DSSP) | Estimated h_ohn1 energy (DSSP) | Estimated h_nho2 energy (DSSP) | Estimated h_ohn2 energy (DSSP) | TCO (DSSP) | Kappa (DSSP) | Alpha (DSSP) | Phi (DSSP) | Psi (DSSP) | Structural Motif (DSSP) | Pocket Volume (Å^3) | Presence at Interface | Local Basic Content (Fraction of Local Neighbors) | Local Acidic Content (Fraction of Local Neighbors) | Local Polar Content (Fraction of Local Neighbors) | Local Cysteine Content (Fraction of Local Neighbors) | Local Structural Content (Fraction of Local Neighbors) | Local Aliphatic Content (Fraction of Local Neighbors) | Local Aromatic Content (Fraction of Local Neighbors) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GAPDH | P04406 | 6ynd | 7.2 | 0.0 | 25.0 | 24.0 | 49.0 | 0.0 | -2.5 | -2.2 | -0.6 | -0.5 | -0.9 | 37.5 | -135.7 | -134.8 | 154.6 | E | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.7 | 0.0 |
Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell
and Lawrence Lab
