DrugMap: GAPDH (KB02)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   KB05
KB05
   KB03
KB03
   
KB02
KB02
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namepeptideinformation
pancreas_CFPAC1
pancreas_BXPC3
pancreas_KP4
pancreas_HUPT4
pancreas_SW1990
pancreas_DANG
pancreas_HUPT3
pancreas_PATU8988T
pancreas_PANC0403
pancreas_MIAPACA2
pancreas_SUIT2
pancreas_PANC1
CYS 152 IISNASCTTNCLAPLAK8067586617214137333633
LTGMAFRVPTANVSVVDLTCR-3835-13423-75-8-7-5710
GAPDHDNA copy numberinformation0.7192877568414631.064267100534991.563441565039581.028696849051411.180764536967491.068536374710191.080581903043150.7779138021377781.084445885240271.311152379774211.235562595890850.805934498060258
GAPDHDNA mutation statusinformation000000000000
GAPDHRNA expressioninformation10.838258481713312.288000889707613.146695948030710.904709877662612.179442626129611.52806334829211.859728892678411.446204526875912.118422024313212.864882556766212.111298714258311.679304150357
GAPDHCRISPR gene dependencyinformation0.980.970.991.000.950.990.961.000.980.990.941.00

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab