DrugMap: GAPDH (KB05)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   
KB05
KB05
   KB03
KB03
   KB02
KB02
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namepeptideinformation
skin_A375
skin_RPMI7951
skin_SKMEL2
skin_HMCB
skin_SKMEL3
skin_G361
skin_UACC257
skin_SKMEL30
skin_MEWO
skin_UACC62
skin_LOXIMVI
skin_WM2664
skin_COLO792
skin_MELJUSO
skin_COLO679
skin_A2058
skin_SKMEL28
skin_IGR1
skin_HS944T
skin_IGR37
skin_RVH421
skin_IPC298
skin_WM793B
skin_MEL182
skin_MEL167
skin_IGR39
skin_CHL1
skin_COLO829
skin_A375S2
skin_A101D
skin_SKMEL24
skin_SH4
skin_HS936T
skin_WM115
skin_C32
skin_COLO853
skin_COLO800
skin_SKMEL5
skin_A431
skin_WM1552C
skin_MELHO
skin_MCC13
skin_MCC26
CYS 152 IISNASCTTNCLAPLAK4118162532152423271926201816-274-183-49291784152313163417100152637-4412147261023
LTGMAFRVPTANVSVVDLTCR-65249-12-9-13-131910-412104-2-11-53-121-73219-1111-591233169-23-3-7619213113-120
GAPDHDNA copy numberinformation1.078423570735960.9299963860156040.9795391812164830.9026255385793910.9861813208207851.023981056887621.013205893088850.9322167004981270.6224969593893761.062378331747341.194224642713860.7665033404461351.088821879571411.009465348222711.28109275858340.9710994013896220.8587497182154861.091841672008030.8015976706776011.054009073578531.091144830628691.090582479692611.318129535116561.018055083142141.154261398141511.020238493770380.957792079883960.9964773112772471.009501584090390.996136686568850.9541548937910881.044198456052231.018576580022880.9344217137617590.9996265483477951.16695295770333
GAPDHDNA mutation statusinformation0000000000000000000000000001000000
GAPDHRNA expressioninformation12.821195991119611.787412873905912.439467308104711.92740761294911.896975644952812.47200537089912.586206476576412.856328256263211.920017825408313.030563688821112.816223689059612.17489448201111.985308297255912.858136449579613.651948610723412.692114176142912.35433203972112.991256099283312.161950647790612.834490801971712.045452527098812.756452077786812.996155679492812.393229553113712.67622156156913.372184896486412.985308297255912.898884759593512.983260847682513.407002147924212.642841438033612.211097393329311.684748620421612.801405239881611.77078775952612.5599506127131
GAPDHCRISPR gene dependencyinformation1.001.001.000.920.980.990.990.961.001.001.001.001.000.841.001.000.970.980.990.630.991.000.990.990.960.98

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab