DrugMap: GAPDH (KB02)

DrugMap cysteine engagement data for:

GAPDH
Gene: 
   
Probe:   KB05
KB05
   KB03
KB03
   
KB02
KB02
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namepeptideinformation
lung_MGH0061
lung_NCIH3122
lung_MGH0651
lung_MGH0261
lung_MGH0732
lung_MGH0653
lung_MGH9153
lung_MGH0752
lung_MGH97967
lung_MGH9521R
lung_MGH92431
lung_MGH91621
lung_MGH8022
lung_MGH8021
lung_MGH8091
lung_MGH9201
lung_MGH1701
lung_MGH100151
lung_MGH1542
lung_MGH100164
lung_MGH90921
lung_ABC1
lung_A549
lung_HCC15
lung_CALU6
lung_MGH1543
lung_MGH1541
lung_MGH8222
lung_MGH1904
lung_NCIH1703
lung_LU65
lung_NCIH1155
lung_NCIH2172
lung_HCC44
lung_CORL23
lung_NCIH1299
lung_NCIH1666
lung_NCIH23
lung_SW1573
lung_NCIH1944
lung_PC14
lung_HCC827
lung_LUDLU1
lung_NCIH1975
lung_NCIH2170
lung_NCIH2122
lung_NCIH1792
lung_NCIH1048
lung_SW1271
lung_NCIH446
lung_NCIH2286
lung_NCIH1793
lung_NCIH1650
lung_CALU1
lung_NCIH358
lung_NCIH2052
lung_MSTO211H
lung_CORL88
lung_SBC5
lung_NCIH196
lung_NCIH146
lung_SHP77
lung_NCIH82
lung_NCIH2291
CYS 152 IISNASCTTNCLAPLAK5168436274475850616761782539563334831728635749472154386961495149583665553751604427423564385523352730255550373119412627
LTGMAFRVPTANVSVVDLTCR40-38-4229-37-15-17-39-37-40-22-3558133172281340-233-123823341711-13-9-135-5-4-776721155-5-46-447118-50231-100311101335-7
GAPDHDNA copy numberinformation0.9728194666275361.093114586402481.124913440027751.349555157779021.604544351647450.9678665261353030.9548857139303710.7635274043269021.017125452240290.9942166386116761.494957939996410.7706196791564611.702510376981241.110718890533851.272917469696591.430778870704611.319082668007081.091306144425930.845605652925131.341151097352230.9174837239815670.9900142993200481.031798900446151.272517149396021.202871177613661.078522020658430.723046625252261.025286286175611.383784148339040.7410215144876221.13359626766411.106342689474221.629370703337991.060638108378020.5559604757956511.628565453418020.6019302319341171.116422794459431.22503623582686
GAPDHDNA mutation statusinformation000000000000000000000000000000000000000
GAPDHRNA expressioninformation11.993893681366212.472360839583912.60455322907912.580941589269112.984418458801112.222855265414512.08058438630411.436399236682811.320969736971811.387748100711312.779678322277711.721141921932112.843862180594911.892960158841612.465362331672212.674545393845913.082681302950412.411722821951411.858602712457113.091137824581112.264970318957412.315659058440412.254438148267313.09396218624911.588480412829812.514048268853211.510022358813812.854284020176213.059952779387111.669726606230212.325502223924712.372973856541212.327861359014710.972046397846910.950045505346512.542838416536110.812979471251511.18574268224712.4075598857255
GAPDHCRISPR gene dependencyinformation0.880.930.921.001.000.981.000.931.001.001.001.001.000.820.910.981.000.970.980.930.991.001.000.980.920.981.000.991.000.930.881.000.971.001.00

Column filtering     
     Off
  Detected in DrugMap     
     Off
  Characterized in DepMap
Lung
n = 64
Bile duct
n = 44
Skin
n = 43
Breast
n = 37
Blood
n = 30
Ovary
n = 25
Central nervous system
n = 17
Colorectal
n = 16
Pancreas
n = 12
Liver
n = 12
Kidney
n = 12
Lymphocyte
n = 12
Esophagus
n = 11
Gastric
n = 11
Uterus
n = 9
Bone
n = 9
Upper aerodigestive
n = 8
Urinary tract
n = 8
Soft tissue
n = 7
Plasma cell
n = 6
Cervix
n = 6
Prostate
n = 5
Thyroid
n = 4
Peripheral nervous system
n = 4
Brain
n = 3
Fibroblast
n = 1

Structural information   (To highlight a cysteine, click a "CYS" button)

Cysteine
Gene
Uniprot Accession
pdb
Depth (Å)
Absolute SASA (Å^2)
Half-Sphere Exposure (up)
Half-Sphere Exposure (down)
Coordination Number
Relative SASA
Estimated h_nho1 energy (DSSP)
Estimated h_ohn1 energy (DSSP)
Estimated h_nho2 energy (DSSP)
Estimated h_ohn2 energy (DSSP)
TCO (DSSP)
Kappa (DSSP)
Alpha (DSSP)
Phi (DSSP)
Psi (DSSP)
Structural Motif (DSSP)
Pocket Volume (Å^3)
Presence at Interface
Local Basic Content (Fraction of Local Neighbors)
Local Acidic Content (Fraction of Local Neighbors)
Local Polar Content (Fraction of Local Neighbors)
Local Cysteine Content (Fraction of Local Neighbors)
Local Structural Content (Fraction of Local Neighbors)
Local Aliphatic Content (Fraction of Local Neighbors)
Local Aromatic Content (Fraction of Local Neighbors)
GAPDHP044066ynd7.20.025.024.049.00.0-2.5-2.2-0.6-0.5-0.937.5-135.7-134.8154.6E0.00.00.00.00.20.00.20.70.0



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Using this data? Please cite Takahashi, Chong, Zhang, et al. (2024) Cell


       Bar-Peled Lab

and Lawrence Lab